Translational control of immune responses: from transcripts to translatomes.
Identifieur interne : 000D81 ( Main/Exploration ); précédent : 000D80; suivant : 000D82Translational control of immune responses: from transcripts to translatomes.
Auteurs : Ciriaco A. Piccirillo [Canada] ; Eva Bjur [Suède] ; Ivan Topisirovic [Canada] ; Nahum Sonenberg [Canada] ; Ola Larsson [Suède]Source :
- Nature immunology [ 1529-2916 ] ; 2014.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Animaux (MeSH), Biosynthèse des protéines (génétique), Biosynthèse des protéines (immunologie), Complexe-1 cible mécanistique de la rapamycine (MeSH), Complexes multiprotéiques (génétique), Facteur-4E d'initiation eucaryote (génétique), Facteur-4E d'initiation eucaryote (immunologie), Humains (MeSH), Phosphoprotéines (génétique), Phosphoprotéines (immunologie), Protéines adaptatrices de la transduction du signal (génétique), Protéines adaptatrices de la transduction du signal (immunologie), Régulation de l'expression des gènes (génétique), Souris (MeSH), Système immunitaire (immunologie), Sérine-thréonine kinases TOR (génétique), Transcription génétique (MeSH).
- MESH :
- génétique : ARN messager, Biosynthèse des protéines, Complexes multiprotéiques, Facteur-4E d'initiation eucaryote, Phosphoprotéines, Protéines adaptatrices de la transduction du signal, Régulation de l'expression des gènes, Sérine-thréonine kinases TOR.
- immunologie : Biosynthèse des protéines, Facteur-4E d'initiation eucaryote, Phosphoprotéines, Protéines adaptatrices de la transduction du signal, Système immunitaire.
- métabolisme : ARN messager.
- Animaux, Complexe-1 cible mécanistique de la rapamycine, Humains, Souris, Transcription génétique.
English descriptors
- KwdEn :
- Adaptor Proteins, Signal Transducing (genetics), Adaptor Proteins, Signal Transducing (immunology), Animals (MeSH), Eukaryotic Initiation Factor-4E (genetics), Eukaryotic Initiation Factor-4E (immunology), Gene Expression Regulation (genetics), Humans (MeSH), Immune System (immunology), Mechanistic Target of Rapamycin Complex 1 (MeSH), Mice (MeSH), Multiprotein Complexes (genetics), Phosphoproteins (genetics), Phosphoproteins (immunology), Protein Biosynthesis (genetics), Protein Biosynthesis (immunology), RNA, Messenger (genetics), RNA, Messenger (metabolism), TOR Serine-Threonine Kinases (genetics), Transcription, Genetic (MeSH).
- MESH :
- chemical , genetics : Adaptor Proteins, Signal Transducing, Eukaryotic Initiation Factor-4E, Multiprotein Complexes, Phosphoproteins, RNA, Messenger, TOR Serine-Threonine Kinases.
- chemical , immunology : Adaptor Proteins, Signal Transducing, Eukaryotic Initiation Factor-4E, Phosphoproteins.
- genetics : Gene Expression Regulation, Protein Biosynthesis.
- immunology : Immune System, Protein Biosynthesis.
- chemical , metabolism : RNA, Messenger.
- Animals, Humans, Mechanistic Target of Rapamycin Complex 1, Mice, Transcription, Genetic.
Abstract
Selective translational control of gene expression is emerging as a principal mechanism for the regulation of protein abundance that determines a variety of functions in both the adaptive immune system and the innate immune system. The translation-initiation factor eIF4E acts as a node for such regulation, but non-eIF4E mechanisms are also prevalent. Studies of 'translatomes' (genome-wide pools of translated mRNA) have facilitated mechanistic discoveries by identifying key regulatory components, including transcription factors, that are under translational control. Here we review the current knowledge on mechanisms that regulate translation and thereby modulate immunological function. We further describe approaches for measuring and analyzing translatomes and how such powerful tools can facilitate future insights on the role of translational control in the immune system.
DOI: 10.1038/ni.2891
PubMed: 24840981
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Piccirillo</name><affiliation wicri:level="4"><nlm:affiliation>1] Department of Microbiology and Immunology, and Microbiome and Disease Tolerance Centre, McGill University, Montreal, Canada. [2] FOCIS Centre of Excellence and Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1] Department of Microbiology and Immunology, and Microbiome and Disease Tolerance Centre, McGill University, Montreal, Canada. [2] FOCIS Centre of Excellence and Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Bjur, Eva" sort="Bjur, Eva" uniqKey="Bjur E" first="Eva" last="Bjur">Eva Bjur</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Topisirovic, Ivan" sort="Topisirovic, Ivan" uniqKey="Topisirovic I" first="Ivan" last="Topisirovic">Ivan Topisirovic</name><affiliation wicri:level="4"><nlm:affiliation>1] Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montréal, Canada. [2] Department of Oncology, McGill University, Montréal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1] Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montréal, Canada. 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Factor-4E (immunology)</term><term>Gene Expression Regulation (genetics)</term><term>Humans (MeSH)</term><term>Immune System (immunology)</term><term>Mechanistic Target of Rapamycin Complex 1 (MeSH)</term><term>Mice (MeSH)</term><term>Multiprotein Complexes (genetics)</term><term>Phosphoproteins (genetics)</term><term>Phosphoproteins (immunology)</term><term>Protein Biosynthesis (genetics)</term><term>Protein Biosynthesis (immunology)</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>TOR Serine-Threonine Kinases (genetics)</term><term>Transcription, Genetic (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>ARN messager (métabolisme)</term><term>Animaux (MeSH)</term><term>Biosynthèse des protéines (génétique)</term><term>Biosynthèse des protéines (immunologie)</term><term>Complexe-1 cible mécanistique de la rapamycine (MeSH)</term><term>Complexes multiprotéiques (génétique)</term><term>Facteur-4E d'initiation eucaryote (génétique)</term><term>Facteur-4E d'initiation eucaryote (immunologie)</term><term>Humains (MeSH)</term><term>Phosphoprotéines (génétique)</term><term>Phosphoprotéines (immunologie)</term><term>Protéines adaptatrices de la transduction du signal (génétique)</term><term>Protéines adaptatrices de la transduction du signal (immunologie)</term><term>Régulation de l'expression des gènes (génétique)</term><term>Souris (MeSH)</term><term>Système immunitaire (immunologie)</term><term>Sérine-thréonine kinases TOR (génétique)</term><term>Transcription génétique (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term><term>Eukaryotic Initiation Factor-4E</term><term>Multiprotein Complexes</term><term>Phosphoproteins</term><term>RNA, Messenger</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term><term>Eukaryotic Initiation Factor-4E</term><term>Phosphoproteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression Regulation</term><term>Protein Biosynthesis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>Biosynthèse des protéines</term><term>Complexes multiprotéiques</term><term>Facteur-4E d'initiation eucaryote</term><term>Phosphoprotéines</term><term>Protéines adaptatrices de la transduction du signal</term><term>Régulation de l'expression des gènes</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Biosynthèse des protéines</term><term>Facteur-4E d'initiation eucaryote</term><term>Phosphoprotéines</term><term>Protéines adaptatrices de la transduction du signal</term><term>Système immunitaire</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Immune System</term><term>Protein Biosynthesis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mechanistic Target of Rapamycin Complex 1</term><term>Mice</term><term>Transcription, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Complexe-1 cible mécanistique de la rapamycine</term><term>Humains</term><term>Souris</term><term>Transcription génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Selective translational control of gene expression is emerging as a principal mechanism for the regulation of protein abundance that determines a variety of functions in both the adaptive immune system and the innate immune system. The translation-initiation factor eIF4E acts as a node for such regulation, but non-eIF4E mechanisms are also prevalent. Studies of 'translatomes' (genome-wide pools of translated mRNA) have facilitated mechanistic discoveries by identifying key regulatory components, including transcription factors, that are under translational control. Here we review the current knowledge on mechanisms that regulate translation and thereby modulate immunological function. We further describe approaches for measuring and analyzing translatomes and how such powerful tools can facilitate future insights on the role of translational control in the immune system. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24840981</PMID><DateCompleted><Year>2014</Year><Month>07</Month><Day>28</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>05</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1529-2916</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Nature immunology</Title><ISOAbbreviation>Nat Immunol</ISOAbbreviation></Journal><ArticleTitle>Translational control of immune responses: from transcripts to translatomes.</ArticleTitle><Pagination><MedlinePgn>503-11</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ni.2891</ELocationID><Abstract><AbstractText>Selective translational control of gene expression is emerging as a principal mechanism for the regulation of protein abundance that determines a variety of functions in both the adaptive immune system and the innate immune system. The translation-initiation factor eIF4E acts as a node for such regulation, but non-eIF4E mechanisms are also prevalent. Studies of 'translatomes' (genome-wide pools of translated mRNA) have facilitated mechanistic discoveries by identifying key regulatory components, including transcription factors, that are under translational control. Here we review the current knowledge on mechanisms that regulate translation and thereby modulate immunological function. We further describe approaches for measuring and analyzing translatomes and how such powerful tools can facilitate future insights on the role of translational control in the immune system. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Piccirillo</LastName><ForeName>Ciriaco A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>1] Department of Microbiology and Immunology, and Microbiome and Disease Tolerance Centre, McGill University, Montreal, Canada. [2] FOCIS Centre of Excellence and Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bjur</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Topisirovic</LastName><ForeName>Ivan</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>1] Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montréal, Canada. [2] Department of Oncology, McGill University, Montréal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sonenberg</LastName><ForeName>Nahum</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, and Goodman Cancer Research Centre, McGill University, Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larsson</LastName><ForeName>Ola</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MOP 67211</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. 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